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Comparison of Labetalol and Nitroglycerin in control of blood pressure and bleeding reduction in septorhinoplasty surgery

Comparison of Labetalol and Nitroglycerin in control of blood pressure and bleeding reduction in septorhinoplasty surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014021712094N4
Enrollment
70
Registered
2014-05-24
Start date
2013-12-06
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasal surgery. Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care

Interventions

Intervention 1: Intervention group 1 : they received nitroglycerin. The nitroglycerin dose rate of 5 mcg / min every 3 to 5 minutes, then to the extent prescribed by 5 mcg / min was added. Interventio
Treatment - Drugs
Intervention group 1 : they received nitroglycerin. The nitroglycerin dose rate of 5 mcg / min every 3 to 5 minutes, then to the extent prescribed by 5 mcg / min was added.
Intervention group 2 : they received labetalol, the starting dose is 5 mg in labetalol group. And to establish anti-hypertension effect desired, can be 5 to 10 mg every 5 minutes once received

Sponsors

Vice Chancellor for Research, Mashhad University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: candidate for nasal surgery; American Society of Anesthesiology (ASA) I and II Exclusion criteria: history of cardiovascular disease; history of hypertension; liver or kidney disease and coagulation disorders; hemoglobin below 10 ; receiving aspirin or other anticoagulation's before surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Mean arterial blood pressure. Timepoint: Before induction, Every 5 minutes to 75 minutes, after induction, during surgery and end of surgery. Method of measurement: Non-invasive monitoring of blood pressure.

Secondary

MeasureTime frame
Volume of bleeding. Timepoint: Before induction, every 5 minutes to 75 minutes, after induction, during surgery and end of surgery. Method of measurement: Total gauze consumption and suction.;Heart rate. Timepoint: Before induction, every 5 minutes to 75 minutes, after induction, during surgery and end of surgery. Method of measurement: Hemodynamic monitoring.;Need for additional drug. Timepoint: Time of measurement: Before induction, every 5 minutes to 75 minutes, after induction, during surgery and end of surgery. Method of measurement: Based on the dose of drug.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMajid Razavi

Mashhad University of Medical Sciences

Razavim@mums.ac.ir+98 51 1852 5209

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026