Effect of brackets coated with nanoparticles in the prevention of dental enamel demineralization

Evaluation of the effect of brackets coated with titanium dioxide nanoparticles in the prevention of dental enamel demineralization and the amount of titanium release in the oral environment during the treatment of fixed orthodontic patients: a randomized controlled clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140215016582N7

Enrollment

Registered

2024-01-08

Start date

2024-01-20

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Caries and demineralization. Dental caries on smooth surface limited to enamel

Interventions

Intervention group: Intervention group: tooth bond with bracket coated by titanium dioxide nanoparticles with vapor deposition method.

Eligibility

Sex/Gender

All

Age

15 Years to 25 Years

Inclusion criteria

Inclusion criteria: Patient ranged 15-25 years old The ability to observe the hygiene of mouth They must have 1-4 repaired yeeth A healthy and flawless immune system Non-use of antibiotics and antibacterial during treatment

Exclusion criteria

Exclusion criteria: Tooth loss due to decay The presence of active caries or prosthetic treatment in the mouth Smoking Periodontal disease Treated with immunosuppressive drugs People with diabetes Pregnancy

Design outcomes

Primary

Measure	Time frame
Tooth demineralization. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Diagnodent device.	—

Secondary

Measure	Time frame
The amount of titanium in saliva. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: ICP MS device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Khodadandehloo

Hamedan University of Medical Sciences

Velayateallah@gmail.com0098 81 8216072

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026