The effect of NIMV on premature infants

Therapeutic effect of NIMV and NCPAP as initial therapy of RDS in premature VLBW infants admitted in Alzahra and Shashid Beheshti hospitals of Isfahan.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014021410026N4

Enrollment

Registered

2014-04-09

Start date

2012-11-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory distress syndrom. Respiratory distress syndrom

Interventions

Intervention 1: For infants in early-NIMV group (non-synchronized mode), NIMV will set at peak inspiratory pressure (PIP) of 16 -20 cmH2O (according to infant’s birth weight and chest wall expansion),

Treatment - Devices

For infants in early-NIMV group (non-synchronized mode), NIMV will set at peak inspiratory pressure (PIP) of 16 -20 cmH2O (according to infant’s birth weight and chest wall expansion), positive end ex

For infants in early-NCPAP group, NCPAP will initiate on a continuous pressure of 5 to 6 cmH2O with a flow of 8 to 10 L/minute

Eligibility

Sex/Gender

All

Age

No minimum to 1 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: premature infants, weighing less than 1500 g and RDS symptoms requires treatment. Exclusion criteria: are major congenital anomalies; respiratory anomalies; orofacial malformations and cyanotic heart diseases.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The effect of NIMV on need for intubation/endotracheal tube ventilation. Timepoint: Within the ?rst 48 h of life. Method of measurement: Clinical evidence of respiratory distress & ABG.;The duration of non-invasive respiratory support. Timepoint: Within the ?rst 48 h of study. Method of measurement: Clinical evidence of respiratory distress $ ?ABG.	—

Secondary

Measure	Time frame
Needed to surfactant. Timepoint: During first 48 h of life. Method of measurement: Daily recorded sheets.;Duration of dependency to oxygen. Timepoint: First month of life. Method of measurement: Daily recorded sheets.;Time to full enteral feeds. Timepoint: During first month of life. Method of measurement: Daily recorded sheets.;Hospitalization time. Timepoint: During first month of life. Method of measurement: Daily recorded sheets.;Pneumothorax. Timepoint: During first month of life. Method of measurement: Daily recorded sheets.	—

Measure

Time frame

Needed to surfactant. Timepoint: During first 48 h of life. Method of measurement: Daily recorded sheets.;Duration of dependency to oxygen. Timepoint: First month of life. Method of measurement: Daily recorded sheets.;Time to full enteral feeds. Timepoint: During first month of life. Method of measurement: Daily recorded sheets.;Hospitalization time. Timepoint: During first month of life. Method of measurement: Daily recorded sheets.;Pneumothorax. Timepoint: During first month of life. Method of measurement: Daily recorded sheets.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ghobad Heidari

Isfahan University of Medical Sciences

ghobadheidari@yahoo.com+98 31 1651 2025

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026