Nail psoriasis. Other psoriasis
Conditions
Interventions
Intervention 1: Intervention group: Intralesional injection of methotrexate (Mylan factory, France) is done in the nail matrix and bed every 3 weeks for 4 sessions. Intervention 2: Control group: Intr
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients between 16 and 70 years of age Clinically- or pathologically confirmed nail psoriasis that have involvement of one or more fingernails with psoriasis
Exclusion criteria
Exclusion criteria: Patients with involvement of 5 or more nails Patients who received systemic or topical medication (for nail) in the last 3 months Patients with skin involvement of more than 20% that need systemic treatment Patients with nail fungal infection History of hypersensitivity reactions to lidocaine, triamcinolone, or methotrexate Diabetic patients Pregnancy Lactation Immunocompromised patients Patients with active peptic ulcer, gastritis, ascitis, and pleural effusion Concomitant use of hepatotoxic drugs, or drugs that interfere with methotrexate metabolism Concomitant radiotherapy Active or severe infection Decreased pulmonary function Renal failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of nail involvement with psoriasis. Timepoint: At the beginning of treatment and weeks 3 ,6, 9, 12, 15, and 23. Method of measurement: modified Nail Psoriasis Severity Index (mNAPSI), measured by inspection and scoring of the severity of psoriasis features in nail matrix and bed. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life index. Timepoint: At the beginning and end of treatment. Method of measurement: Dermatology quality of life index questionnaire.;Pain severity during injection. Timepoint: At the beginning of treatment and weeks 3 ,6, 9, 12, 15, and 23. Method of measurement: illustrated numerical rating scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMozhdeh Sepaskhah
Shiraz University of Medical Sciences
Outcome results
None listed