Comparison of the effect of cysteamine cream and hydroquinone cream in the treatment of acne pigmentation

Comparison of the therapeutic efficacy of cysteamine 5% cream with Hydroquinon 4% cream in acne-induced postinflammatory hyperpigmentation patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140212016557N5

Enrollment

Registered

2019-12-03

Start date

2019-04-06

Completion date

Unknown

Last updated

2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne-induced post-inflammatory hyperpigmentation. Postinflammatory hyperpigmentation

Interventions

Intervention 1: Intervention group: Cysteamine 5% cream (Scentispharma, Switzerland) is applied once every night for 15 minutes for 4 months on the face skin. Intervention 2: Control group: Hydroquino

Eligibility

Sex/Gender

All

Age

14 Years to 40 Years

Inclusion criteria

Inclusion criteria: Facial acne post-inflammatory hyperpigmentation No active acne lesion after or during treatment of acne

Exclusion criteria

Exclusion criteria: Receiving any depigmenting agent since 2 months before being recruited in the study Pregnancy Lactation History of hypersensitivity to ingredients of either drugs Patients taking oral contraceptive pills

Design outcomes

Primary

Measure	Time frame
Melanin index. Timepoint: before intervention and 2 and 4 months after intervention. Method of measurement: SkinColorCatch instrument.	—

Secondary

Measure	Time frame
Determination of postacnehyperpigmentation index (PAHPI). Timepoint: before intervention and 2 and 4 months after intervention. Method of measurement: postacnehyperpigmentation index (PAHPI) formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMozhdeh Sepaskhah

Shiraz University of Medical Sciences

sepaskhah@sums.ac.ir+98 71 3212 5239

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026