Melasma. Chloasma
Conditions
Interventions
Intervention 1: Intervention group: Cysteamine 5% cream (Scentispharma, Switzerland) is applied once every night for 15 minutes for 4 months on the face skin. Intervention 2: Control group: ?ydroquino
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Epidermal melasma confirmed by Wood's lamp Duration of melasma more than 6 months Age 18 to 50 years
Exclusion criteria
Exclusion criteria: Dermal melasma OCP consumption during or in the past 3 months before the study Consumption of oral or topical corticosteroids on the site of melasma during the study Intolerance to hydroquinone or cysteamine as severe irritation Other pigmentary disorders Pregnancy Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Melanin index. Timepoint: before intervention and 2 and 4 months after intervention. Method of measurement: SkinColorCatch instrument. | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Melasma Area and Severity Scale score. Timepoint: before intervention and 2 and 4 months after intervention. Method of measurement: modified Melasma Area and Severity Scale score formula.;Lee's investigator global assessment score. Timepoint: 2 and 4 months after intervention. Method of measurement: 5-point Likert scale for Lee's investigator global assessment score.;Lee's patient global assessment score. Timepoint: 2 and 4 months after intervention. Method of measurement: 5-point Likert scale for Lee's patient global assessment score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMozhdeh Sepaskhah
Shiraz University of Medical Sciences
Outcome results
None listed