Cutaneous Leishmaniasis. Cutaneous leishmaniasis
Conditions
Interventions
Intervention 1: In control group, patients receive intralesional glucantime injection weekly for 4-8 weeks. Intervention 2: In intervention group, weekly intralesional injection of glucantime starts f
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
10 Years to 40 Years
Inclusion criteria
Inclusion criteria: positive direct smear of the lesion in terms of leishman bodies patient has indication of topical treatment according to the physician less than six month has elapsed since the manifestation of lesion patient has not received any previous treatment for cutaneous leishmaniasis intervention group has normal values for CBC;G6PD;LFT location of lesion is either on upper limbs or face
Exclusion criteria
Exclusion criteria: sensitivity to glucantime (severe topical reaction, anaphylaxis). absence of regular follow-ups existence of secondary infection in lesion use of other treatments during the study dapsone side effects including methemoglobinemia, hemolytic anemia, agranulocytosis, peripheral neuropathy, hypersensitivity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in size of the lesion. Timepoint: At the end of each week. Method of measurement: based on lesion induration measured by a caliper. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: weekly. Method of measurement: clinical evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzadeh Mohammadi
Mashhad University of Medical Sciences
Outcome results
None listed