The effect of synbiotic supplementation in patients with metabolic syndrome

The effect of synbiotic supplementation on anthropometric parameters, lipid profiles, total antioxidant capacity and malondialdehyde in patients with metabolic syndrome, an approach to prevent cardiovascular disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140208016529N5

Enrollment

Registered

2020-02-02

Start date

2019-12-14

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic syndrome. Metabolic disorder, unspecified

Interventions

Intervention 1: Intervention group: Synbiotic Supplement, as 500 mg capsule, twice a day orally, for 8 weeks. Intervention 2: Control group: Placebo (as 500 mg capsule, maltodexterin), quite simila

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Willingness to participate in projects Women and men aged 20-55 years Waist circumference =88 cm in women and waist circumference =102 cm in men, serum triglyceride =150 mg/dl, serum HDL cholesterol 25 kg/m2

Exclusion criteria

Exclusion criteria: Mental illness, cancer, thyroid, cardiovascular, pulmonary, kidney, liver, eating disorders and digestive diseases Pregnancy or lactation or menopause Participate in weight loss or weight loss programs 3 months before the start of the study Use of Probiotic, Prebiotic and Synbiotic Foods, Antibiotic Antioxidants, Multivitamin, Nicotinic Acid and any dietary supplement 2 months before starting the study Drugs affecting appetite and body weight and anti-inflammatory drugs A history of allergies to pro-biotic, prebiotic and maltodextrin products

Design outcomes

Primary

Measure	Time frame
Weight. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Scale-mounted stadiometer(Seca).;Waist circumference. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Flexible tape.;High density lipoprotein (HDL). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Triglyceride. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Body mass index (BMI). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: BMI=weight(kg)/square of height(m)2.	—

Measure

Time frame

Weight. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Scale-mounted stadiometer(Seca).;Waist circumference. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Flexible tape.;High density lipoprotein (HDL). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Triglyceride. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Body mass index (BMI). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: BMI=weight(kg)/square of height(m)2.

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Secondary

Measure	Time frame
Hip circumference. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Flexible tape.;Malondialdehyde (MDA). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Total antioxidant capacity. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Body fat Percent. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Body composition analyzer.;Waist circumference to Hip circumference ratio (WHR). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: WHR=Waist circumference (cm)/Hip circumference (cm).;Low density lipoprotein (LDL). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Energy content of food. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Food record questionnaire.;Physical activity energy expenditure. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Metabolic equivalent of tasks questionnaire.	—

Measure

Time frame

Hip circumference. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Flexible tape.;Malondialdehyde (MDA). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Total antioxidant capacity. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Body fat Percent. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Body composition analyzer.;Waist circumference to Hip circumference ratio (WHR). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: WHR=Waist circumference (cm)/Hip circumference (cm).;Low density lipoprotein (LDL). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Colorimetric method.;Energy content of food. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Food record questionnaire.;Physical activity energy expenditure. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Metabolic equivalent of tasks questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hasan Entezari

Esfahan University of Medical Sciences

entezari@hlth.mui.ac.ir+98 31 3792 3171

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026