Nonalcoholic Fatty Liver Disease.. Nonalcoholic steatohepatitis (NASH)
Conditions
Interventions
Intervention 1: The energy requirements of intervention group are calculated with Mifflin-St Jeor equation on the basis of weight, height, age, and sex of each participant. Take into account the patie
Sponsors
Vice Chancellor for Research, Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: Over-weight or obese patients with the nonalcoholic fatty liver disease confirmed with imaging techniques increased levels of liver enzymes (serum levels of alanine aminotransferase and aspartate aminotransferase more than 40 U/L); Body Mass Index (BMI) of them is greater than 24.9 and lower than 40
Exclusion criteria
Exclusion criteria: Alcohol consumption Pregnant and lactating women Any known forms of hepatic or metabolic disease except NAFLD, such as hereditary hemochromatosis, Wilson’s disease, cirosis, other metabolic disease history of gastric bypass or intestine surgery Taking hepatotoxic drugs such as calcium channel blocker, methotrexate, amiodarone, chloroquine and anti inflammatory drugs; Using nutrition supplements or vegetarian diets Hormone Therapy Patients with a history of hypothyroidism, Cushing’s syndrome renal failure kidney stones. Participants with less than 80% of adherence to the dietary plan are going to be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver enzymes (ALT, AST, ALP). Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Using Microgram/ml - laboratory kit.;Lipid profile (TG, LDL, HDL, Total cholestrol). Timepoint: The first day of the study and the last day of 12th week. Method of measurement: laboratory kit.;Liver steatosis index. Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Waist to hip ratio. Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Non-stretchable tape without any pressure.;Body Mass Index (BMI). Timepoint: The first day of the study and the last day of 12th week. Method of measurement: Weight (kilograms) divided by the square of height (meters).;Sistolic and diastolic blood pressure. Timepoint: The first day of the study and the last day of 12th week. Method of measurement: By mercury sphygmomanometer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNazila Garousi
Esfahan University of Medical Sciences
Outcome results
None listed