Effects of different tidal volumes on hemodynamic indices during deliberate hypotension by using nitroprosside & nitroglycerin

Comparative evaluation of effects of different tidal volumes of mechanical ventilation on hemodynamic indices during deliberate hypotension by using nitroprosside & nitroglycerine in ear microsurgery patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2014020516415N2

Enrollment

Registered

2014-07-14

Start date

2014-02-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug induced Hypotension. Hypotension due to drugs

Interventions

Intervention 1: First group: changing tidal volume between 5, 10 and 15 ml/kg during infusion of nitroglycerin. Nitroglycerin infusees in 0.5 mic/kg after induction of anesthesia and increase till 30%

Treatment - Drugs

First group: changing tidal volume between 5, 10 and 15 ml/kg during infusion of nitroglycerin. Nitroglycerin infusees in 0.5 mic/kg after induction of anesthesia and increase till 30% decrease in me

Second group: changing tidal volume between 5, 10 and 15 ml/kg during infusion of Na nitroprusside. Na Nitroprusside infusees in 1 mic/kg after induction of anesthesia and increase till 30% decrease

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: ASA 1 and 2; non smokers; no cardiopulmonary and renal disease; candidates for elective middle ear microsurgery. Exclusion criteria: Bleeding more than 2cc/kg; bronchospasm during surgery; need to other hypotensive drugs other than drugs of study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart rate, Blood pressure, Cardiac output, Stroke Volume. Timepoint: At the end of each tidal volume trial. Method of measurement: Measurement by anesthesia monitoring system and TECO (Trans Esophageal Cardiac Output measurement).	—

Secondary

Measure	Time frame
Peak airway pressure, Plateu airway pressure. Timepoint: At the end of each trial different tidal volumes. Method of measurement: By ventilator of anesthesia mashine.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGolparvar M MD

Isfahan University of Medical Sciences

golparvar@med.mui.ac.ir+98 31 1624 9031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026