knee osteoarthritis. Gonarthrosis [arthrosis of knee]
Conditions
Interventions
Intervention 1: Intervention group : platelet rich plasma, knee intraarticular injection, 4 to 6 milliliter, 2 times, 4 weeks interval. Intervention 2: Control group:exercise,quadriceps strengthening
Treatment - Drugs
Treatment - Other
Intervention group : platelet rich plasma, knee intraarticular injection, 4 to 6 milliliter, 2 times, 4 weeks interval
Control group:exercise,quadriceps strengthening and hamstring stretching,10 times for 10 seconds,3 times a day
Sponsors
Physical Medicine and Rehabilitation Department of Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: arthralgia since past 3 months; radiologic evidence of articular damage (grade 1-4 of Kellgren-Lawrence scale) based on knee OA criteria of ACR. Exclusion criteria: systemic diseases such as diabetes mellitus and collagen vascular disorders; history or presence of cancer or malignant disorders; any infection and active wound of the knee; presence of immunosuppressive, autoimmune and platelet disorders; treatment with anticoagulant and anti-platelet medications 10 days before injection; use of NSAIDs 2 days before injection; history of knee articular injections of corticosteroids 3 weeks or use of systemic corticosteroids 2 weeks before PRP injections; hemoglobin measures of less than 12 g/dl and platelet counts of less than 150,000 per micro liter; recent history of severe trauma to the knee; age less than 45 or over 75 year; history of vasovagal shock; pregnancy; breastfeeding; genu valgum/varum greater than 20 degrees; contraindication for MRI including aneurysm clips,pacemaker,metallic devices and claustrophobia.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cartilage lesion. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.;Joint stiffness. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Function. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: before intervention & 6 months after intervention. Method of measurement: WOMAC questionnaire.;Knee pain. Timepoint: before intervention & 6 months after intervention. Method of measurement: VAS.;Bone marrow edema. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.;Meniscus lesion. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria.;Synovitis. Timepoint: before intervention & 6 months after intervention. Method of measurement: WORMS criteria. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactElham Ghorbani
Shahid modarres hospital
Outcome results
None listed