The effects of perioperative probiotic treatment after colorectal surgery

The effects of perioperative probiotic treatment on postoperative complications after colorectal surgery-a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140203016473N9

Enrollment

120

Registered

2018-05-12

Start date

2018-03-21

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Malignant diseases of colon. Condition 2: Benign diseases of the colon, rectum, anus and anal canal. Condition 3: Foreign body in colon. Condition 4: Other specified diseases of intestine. Malignant neoplasm of colon Benign neoplasm of colon, rectum, anus and anal canal Foreign body in colon, initial encounter Other specified diseases of intestine

Interventions

Intervention 1: Intervention group: Pre- and postoperative treatment by oral probiotic drug after colorectal surgery. Intervention 2: Control group: Routine pre- and postoperative treatment of colorec

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Need for any elective colorectal surgery Nurgery is done by an attending surgeon Good nutritional status

Exclusion criteria

Exclusion criteria: No consent to enter the study Small or large bowel obstruction Anticoagulant consumption ASA class IV Inflammatory bowel disease History of chemotherapy Transplant recipients Liver cirrhosis Antibiotic consumption in the week before surgery Steroid consumption Diabetes mellitus Pregnancy or breastfeeding Immunodeficiency of any cause

Design outcomes

Primary

Measure	Time frame
Anastomosis rupture. Timepoint: Daily till 30 days after the operation. Method of measurement: Physical examination.;Surgical site infection. Timepoint: Daily till 30 days after the operation. Method of measurement: Physical examination.;Fascia dehiscence. Timepoint: Daily till 30 days after the operation. Method of measurement: Physical examination.;Pulmonary infection. Timepoint: Daily till 30 days after the operation. Method of measurement: Chest x-ray if clinically indicated.;Urinary infection. Timepoint: Daily till 30 days after the operation. Method of measurement: Urinalysis if clinically indicated.;Total duration of hospital stay. Timepoint: Daily. Method of measurement: Total duration of hospital stay till discharge.;Mortality. Timepoint: Daily. Method of measurement: Report of death by attending physician.	—

Measure

Time frame

Anastomosis rupture. Timepoint: Daily till 30 days after the operation. Method of measurement: Physical examination.;Surgical site infection. Timepoint: Daily till 30 days after the operation. Method of measurement: Physical examination.;Fascia dehiscence. Timepoint: Daily till 30 days after the operation. Method of measurement: Physical examination.;Pulmonary infection. Timepoint: Daily till 30 days after the operation. Method of measurement: Chest x-ray if clinically indicated.;Urinary infection. Timepoint: Daily till 30 days after the operation. Method of measurement: Urinalysis if clinically indicated.;Total duration of hospital stay. Timepoint: Daily. Method of measurement: Total duration of hospital stay till discharge.;Mortality. Timepoint: Daily. Method of measurement: Report of death by attending physician.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzad Kakaei

Tabriz University of Medical Sciences

fkakaei@yahoo.com+98 41 3334 1317

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026