The Effect of Naproxen Patch on Relieving Orthodontic Pain by Evaluation of VAS and IL-1ß Inflammatory Factor

The Effect of Naproxen Patch on Relieving Orthodontic Pain by Evaluation of VAS and IL-1ß Inflammatory Factor: A split-mouth study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140203016466N7

Enrollment

Registered

2018-04-30

Start date

2017-12-25

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of Naproxen Patch on Relieving Orthodontic Pain by Evaluation of VAS and IL-1ß Inflammatory Factor.

Interventions

Intervention 1: Intervention group: Naproxen patch. Intervention 2: Control group: Placebo patch.

Eligibility

Sex/Gender

All

Age

22 Years to 40 Years

Inclusion criteria

Inclusion criteria: Generally healthy patients, No periodontal or endodontic disease, Presence of bilateral first and second maxillary molars and second maxillary premolars, Tight posterior teeth contacts with no spacing, Presence of antagonist teeth without posterior open bite, No psychologic or mental disorder.

Exclusion criteria

Exclusion criteria: Patients who did not participate in the follow up sessions, had no pain on both sides, took systemic or topical painkillers except prescribed patches, removed separators, did not used patches as prescribed, and did not fill VAS questionnaire on time or lacked cooperation were excluded.

Design outcomes

Primary

Measure	Time frame
-Patch type -Time. Timepoint: 2 & 6 hours, sleep time, 24 hours, days 2, 3 and 7 day. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactYasamin Babaee Hemmati

Rasht University of Medical Sciences

yasi.10482@gmail.com+98 13 3332 0298

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026