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Effect of zinc sulphate on mucositis.

Comparison between zinc sulphate and placebo capsules in the prevention of mucositis in patients with leukemia under chemotherapy: a clinical trial study

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014012713690N2
Enrollment
86
Registered
2014-03-08
Start date
2012-04-01
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

leukaemia. Lymphoid leukaemia, Myeloid leukaemia

Interventions

Intervention 1: Intervention group: administration of 50 mg zinc sulphate capsule, three times daily for 14 days from the first day of chemotherapy. Intervention 2: Control group: administration of pl
Prevention
Intervention group: administration of 50 mg zinc sulphate capsule, three times daily for 14 days from the first day of chemotherapy.
Control group: administration of placebo capsules, three times daily for 14 days from the first day of chemotherapy.

Sponsors

Vice chancellor for research affairs of Shiraz University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria of the study were leukemia patients with 18 years old or above, under chemotherapy, be alerted and oriented, and able to swallow capsule and did not show the mucositis symptoms such as ulcers, erythema, oedema, painful and dysphasia.The patients with any ulcer in their mouth, pregnant and lactating women, individuals under head and neck radiotherapy and patients who had the allergic to zinc were excluded from the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Mucositis. Timepoint: Fourth, seventh,14th day from starting chemotherapy. Method of measurement: JP Donnelly and Colleagues questionnaire, and World Health Organization mucositis scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoume Rambod

Shiraz University of Medical Science

rambodm@sums.ac.ir+98 71 1647 4258

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026