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Efficacy of glucocorticoids and cyclophosphamide in the treatment of paraquat poisoning

Effect of pulse therapy with glucocorticoids and cyclophosphamide in patients with paraquat poisoning

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014012611873N2
Enrollment
46
Registered
2014-03-17
Start date
2013-01-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

poisoning with the pesticide paraquat.

Interventions

Intervention 1: ent emergency hemodialysis in the fastest time possible. After the dialysis, the intervention group received 15 mg/Kg CP for two days and 1g MP for three days. Each drug infused in 200
Treatment - Drugs
Placebo
ent emergency hemodialysis in the fastest time possible. After the dialysis, the intervention group received 15 mg/Kg CP for two days and 1g MP for three days. Each drug infused in 200 cc dextrose sal
After the initial measures, including gastric lavage and administration of activated charcoal and two charcoal dialysis. The control group consisted of normal saline placebo is used, 200 cc given intr

Sponsors

Ahvaz JondyShapour University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: approved the pesticide paraquat during the last 24; moderate to severe poisoning with this herbicide The exclusion criteria: In addition to any other pesticide paraquat; the underlying liver disease - kidney - lung; The incidence of treatment-related complications during interventional treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Kidney failure. Timepoint: Daily during treatment. Method of measurement: BUN & Cr..Cr: 1.4 mg/dl (i.e., mean normal value + 2 standard deviations).;Mortality. Timepoint: Constantly during treatment. Method of measurement: Observation.;Hepatitis (liver failure). Timepoint: Daily during treatment. Method of measurement: (ST) and(ALT) values were > 70 U/L (normal valueis 3.0 mg/dl (normal valueis < 1.4 mg/dl).;Hypoxia. Timepoint: Daily during treatment. Method of measurement: PaO2 < 80 mm Hg at roomair.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Ahmad Ghorbani

Ahvaz Jondishapour University of Medical Sciences

ahmadghorbanidr@yahoo.com+98 61 1333 5935

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026