The effects of probiotic chewable tablet on saliva’s S. Mutans counts and pH

The effects of probiotic (S. salivarius) chewable tablet on saliva’s S. Mutans counts and pH in children with cleft lip and palate (CLP)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140126016372N4

Enrollment

Registered

2020-10-31

Start date

2020-07-22

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cleft lip and plate. Cleft palate with cleft lip

Interventions

Intervention 1: Intervention group: Will receive 90 chew-able Probiotic tablet "Lactogum" according to specified usage protocol included in drug package. They are supposed to take 1 pill every day dur

Eligibility

Sex/Gender

All

Age

5 Years to No maximum

Inclusion criteria

Inclusion criteria: Having cleft lip and palate Lack of any systemic diseases Aged older than 5 years old Ability to chew the tablet

Exclusion criteria

Exclusion criteria: Having any oral surgery during passed 2 months Taking any drug effecting on bacterial growth, such as: antibiotics and cortons Undergoing any treatment interfering with study Using antibacterial mouthwash

Design outcomes

Primary

Measure	Time frame
S. mutans colony count. Timepoint: Before and after 90 days of intervention. Method of measurement: Palate Colony Count method.;Saliva pH. Timepoint: Before and after 90 days of intervention. Method of measurement: Calibrated laboratory digital pH analyzer.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Rahimi

Shiraz University of Medical Sciences

nikaeinf@sums.ac.ir+98 71 3212 7001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026