Radiation induced xerostomia. Dry mouth, unspecified
Conditions
Interventions
Intervention 1: Intervention group 1: Hypozalix 100 mL artificial saliva sprays, three times a day, every time two puffs, for 4 weeks. Intervention 2: Intervention group 2: Sachets of Malva sylvestris
Treatment - Drugs
Intervention group 1: Hypozalix 100 mL artificial saliva sprays, three times a day, every time two puffs, for 4 weeks.
Intervention group 2: Sachets of Malva sylvestris and Alcea digitata formulation, three times a day, each time one sachet into a cup of boiling water, stirred, and after cooling, drink it. For 4 weeks
Sponsors
School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center,Shahid Behes
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: xerostomia at least grade 1 based on clinical grading CTC; adverse event 4; age between 20 to 70 years old; physically and mentally able to fill out a questionnaire; willingness to participate in the study and informed consent; at least three months after the end of radiotherapy; not drinking alcohol; drugs affecting the salivary glands like antidepressant, opioids, antihypertensive, antihistamines, diuretics, all kind of mouthwash and artificial saliva; no history of connective tissue disease like Sjogren, rheumatoid arthritis, lupus, liver disease, kidney disease, major depression, diseases involving salivary glands, diabetes, chronic diseases such as diarrhea cause dehydration; the absence ofneutropenia, immunosuppression, myelosuppression Exclusion criteria: sudden changes in systemic conditions like that a patient requires extensive chemotherapy and surgical interventions; failure/ need parenteral nutrition (TPN) or hospitalization; unwillingness to continue participation in the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Xerostomia. Timepoint: Before interventin & weeks 2 and 4 after intervention. Method of measurement: VAS scale (determined by Question from patient) & Xerostomia Grade (determined by clinical examination).;Quality of life. Timepoint: Before interventin and 4 weeks after intervention. Method of measurement: EORTC questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other Symptoms. Timepoint: Before interventin and 4 weeks after intervention. Method of measurement: Question from patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactGhazaleh Heydarirad M.D
School of Traditional Medicine Traditional Medicine and Materia Medica Research Center Shahid Behesh
Outcome results
None listed