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The effect of liothyronine on prevention of electroconvulsive therapy-induced memory impairment in patients with major depressive disorders

The effect of liothyronine on prevention of electroconvulsive therapy-induced memory impairment in patients with major depressive disorders

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201401122660N2
Enrollment
80
Registered
2014-01-31
Start date
2014-01-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder. Depressive episode

Interventions

Intervention 1: Intervention group: will receive two tablets of liothyronine 25 mcg daily at morning since the first swssion untill last session of ECT. Intervention 2: Control group: will receive two
Treatment - Drugs
Placebo
Intervention group: will receive two tablets of liothyronine 25 mcg daily at morning since the first swssion untill last session of ECT
Control group: will receive two tablets of placebo at morning since the first swssion untill last session of ECT

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: The major inclusion criteria are major depressive disorder patients with 20-50 years old who are candidates of ECT. The major exclusion criteria are contrandication for liothyronine therapy; substance and alchol adiction; brain organic disorders and mental retardation; thyroid dysfunction and ECT less than 6 session.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Memory impairment. Timepoint: Befor intervention, two months after completion intervention. Method of measurement: Wechsler Memory Scale- Revised.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasood Nouri

Tabriz University of Medical Sciences

Nourima@tbzmed.ac.ir+98 41 1380 4486

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 5, 2026