Infertility. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: Participants receive oral nifedipine tablets ,20 Mg single dose 30 minutes before embryo transfer. Intervention 2: Control group: no intervention.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 39 Years
Inclusion criteria
Inclusion criteria: 20-39 years of age Fresh embryo transfer Body mass index :18-29 American Society Anesthesiologist physical status classification system I
Exclusion criteria
Exclusion criteria: History of hypertension History of hypotension Abnormal uterine cavity Contraindication for the use of Estrogen and Progesterone and Nifedipine Administration of drugs that interact with cytochrome P450 activity including azole antifungals, cimetidine, cyclosporine, erythromycin, quinidine, terfenadine, warfarin, benzodiazepines, flecainide, imipramine, propafenone and theophylline within 3 months prior to study enrollment Serum follicle-stimulating hormone (FSH) level >20mIU/mL on days 2-4 of the menstrual cycle Irregular heart beat
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasonography.;Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: BHCG test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure Variation. Timepoint: In three intervals including at the time of anesthesia induction, end of anesthesia, and in recovery time. Method of measurement: With a pressure gauge.;Implantation rate. Timepoint: In pregnancy. Method of measurement: The implantation rates will calculated as the number of gestational sacs divided by the number of embryos transferred to the uterus.;Multiple pregnancy rate. Timepoint: After pregnancy. Method of measurement: Ultrasonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoomeh Nataj Majd
Tehran University of Medical Sciences
Outcome results
None listed