The effect of dexmedetomidine on cognitive impairment after pelvic or femoral orthopedic surgery

Comparison of dexmedetomidine and normal saline (as placebo) prior to surgery on premature cognitive impairment after surgery in elderly patients who are candidates for pelvic orthopedic surgery under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140109016151N7

Enrollment

Registered

2018-11-23

Start date

2017-12-22

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive disorder. Mild cognitive impairment

Interventions

Intervention 1: Intervention group: 10 minutes before starting surgery, 1 µg / kg Dexmedetomidine is injected for the patients. Intervention 2: Control group: 10 minutes before surgery, physiological

Eligibility

Sex/Gender

All

Age

60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients aged 60 to 80 years Candidate for pelvic or femoral orthopedic surgery Informed consent

Exclusion criteria

Exclusion criteria: dexmedetomidine allergy very low blood pressure history of mental and psychological disorders history of central nervous system diseases, such as brain damage, as well as neurological and neurological surgeries History of impaired endocrine function in the patients electrolyte disturbances history of treatment with corticosteroids in the near past dependence on alcohol or narcotics

Design outcomes

Primary

Measure	Time frame
Postoperative cognitive disorder. Timepoint: 1 day before surgery, 24 and 48 hours after surgery. Method of measurement: The MMSE test (Mini-Mental State Examination).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Pournajafian

Iran University of Medical Sciences

a-pournajafian@tums.ac.ir+98 21 8894 6762

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026