Multiple trauma. Unspecified multiple injuries
Conditions
Interventions
Intervention 1: 3 grams of NAC every 6 hours with slow intravenous infusion for 72 hours. Intervention 2: No specific intervention in control group other than routine treatment.
Treatment - Drugs
3 grams of NAC every 6 hours with slow intravenous infusion for 72 hours
No specific intervention in control group other than routine treatment
Sponsors
Vice Chancellor for Research of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: ICU admission fallowing trauma; need for mechanical ventilation ; FiO2 more than 50% ; At least two Systemic Inflammatory Response(SIRS) criteria (Body temperature more than 38°C or less than 36°C, Heart rate more than 90 beats/min, Respiratory rate more than 20 breath/min or PaCo2 less than 32 mm Hg, WBC more than 12,000 cells/mm3, or less than 4000 cells/mm3, or more than 10% immature (band) cells) Exclusion criteria:Age lower than 18 ; Acute Physiology and Chronic Health Evaluation(APACHE) II score lower than 15 ; Central Venous Pressure (CVP) > 18 mmHg ; Systolic Blood Pressure < 90 mmHg or Mean Arterial Pressure (MAP) < 60 mmHg ; Serum Creatinine = 2 mg/dl; urine output less than 0.5 ml/Kg/hour; liver dysfunction (defined as the presence of hepatic cirrhosis or concentration of serum trans-aminases greater than third times the upper limit of normal range) ; history of myocardial infarction or heart failure (EF< 40%) and those received N-acetyl Cysteine (NAC) before initiation of study were excluded from the study
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunoglobulin M. Timepoint: baseline, day 1, day 3 and day 5. Method of measurement: laboratory study.;Glutathione. Timepoint: baseline, day 1, day 3 and day 5. Method of measurement: laboratory study.;Human ß-defensin 2. Timepoint: baseline, day 1, day 3 and day 5. Method of measurement: laboratory study. | — |
Secondary
| Measure | Time frame |
|---|---|
| SOFA score. Timepoint: baseline, days 1,2,3,4 and 5. Method of measurement: standard chart.;WBC. Timepoint: baseline, days 1,2,3,4 and 5. Method of measurement: laboratory study.;Absolute neutrophil count. Timepoint: baseline, days 1,2,3,4 and 5. Method of measurement: laboratory study. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactprofessor Mojtaba Mojtahedzadeh
Pharmaceutical Sciences Research Center of the Tehran University of Medical Sciences
Outcome results
None listed