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Intravenous acetaminophen and remifentanil on the airway response in endoscopic sinus surgery

Comparison of intravenous acetaminophen and remifentanil on the airway response to tracheal tube in endoscopic sinus surgery, during and the end of anesthesia: a clinical trial study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2014010714199N4
Enrollment
70
Registered
2014-03-13
Start date
2012-07-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cough. cough

Interventions

Intervention 1: In the first group, Remifentanil infusion 0/1 µg/kg /min has continued since the nasal tampons were inserted by surgeon until trachea extubation. Intervention 2: In the second group,
Prevention
In the first group, Remifentanil infusion 0/1 µg/kg /min has continued since the nasal tampons were inserted by surgeon until trachea extubation.
In the second group, remifentanil infusion was discontinued at the last 20 minutes of operation and acetaminophen perfusion(1 gr diluted in 100 cc of normal saline solution with 50 cc syringes in the

Sponsors

Vice chancellor for research, Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patient's desire to participate in the study and informed consent, ASA1 eligibility criteria, 20-50 years old, Candidate for sinus surgery. Exclusion criteria: Hypertensive, Asthma, Sensitivity to acetaminophen, Sensitivity to narcotic drugs, Chronic obstructive pulmonary disease, A sign of the difficult airway in examination, Aspiration risk, Recent infection of the airways, Chronic cough and liver disorders.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Cough. Timepoint: At the end of surgery. Method of measurement: Observation and Minogue grading.

Secondary

MeasureTime frame
Heart rate. Timepoint: Heart rate was recorded at T0 (When the nasal tampons were inserted by surgeon), at T1 (During normal spontaneous breathing) and at T2 (5 min after tracheal extubation). Method of measurement: Taking the pulse.;The mean arterial pressure. Timepoint: The mean arterial pressure was recorded at T0 (When the nasal tampons were inserted by surgeon), at T1 (During normal spontaneous breathing) and at T2 (5 min after tracheal extubation). Method of measurement: Pressure gauge.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Valiollah hassani

Rasoul Akram Hospital, Ear-Nose-Throat [ENT] operating room, Department of ear-Nose-Throat [ENT]

valiollah_hassani@yahoo.com+98 21 6435 2458

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026