Effect of oral clonidine on hemodynamics and recovery status of patients undergoing laparoscopic cholecystectomy

Effect of premedication with oral clonidine on hemodynamics and recovery status of patients undergoing laparoscopic cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20140107016117N5

Enrollment

120

Registered

2020-02-01

Start date

2020-01-21

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of oral clonidine on hemodynamic status and recovery after cholecystectomy surgery.. Other complications of anesthesia

Interventions

Intervention 1: Intervention group: The patients of this group will receive 0.2 mg clonidine orally with water . Intervention 2: Control group: this group will receive placebo similar to intervention

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: All ASA I patients aged 20-65 years who are candidate for total elective laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: Patients with systemic diseases(cardiovascular, pulmonary, liver and kidney,...) Blood loss over 10% Drug addiction Alpha-beta-blocker drugs

Design outcomes

Primary

Measure	Time frame
Systolic and diastolic blood pressure. Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes and in recovery every 15 minutes until get out of recovery. Method of measurement: Mercury barometer.;Mean arterial pressure(MAP). Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes and in recovery every 15 minutes until get out of recovery. Method of measurement: Mercury barometer.;Heart rate. Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes and in recovery every 15 minutes until get out of recovery. Method of measurement: Counting in each minutes.;Partial pressure of end tidal of carbondioxide. Timepoint: From the beginning of anesthesia and then every 30 minutes. Method of measurement: Using the Copnograph.;Saturation of peripheral oxygen. Timepoint: From the beginning of anesthesia and then every 30 minutes. Method of measurement: Via the Pulse Oximeter.	—

Measure

Time frame

Systolic and diastolic blood pressure. Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes and in recovery every 15 minutes until get out of recovery. Method of measurement: Mercury barometer.;Mean arterial pressure(MAP). Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes and in recovery every 15 minutes until get out of recovery. Method of measurement: Mercury barometer.;Heart rate. Timepoint: From the beginning of anesthesia to 30th minute,every 5 minutes and after that every 15minutes and in recovery every 15 minutes until get out of recovery. Method of measurement: Counting in each minutes.;Partial pressure of end tidal of carbondioxide. Timepoint: From the beginning of anesthesia and then every 30 minutes. Method of measurement: Using the Copnograph.;Saturation of peripheral oxygen. Timepoint: From the beginning of anesthesia and then every 30 minutes. Method of measurement: Via the Pulse Oximeter.

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Secondary

Measure	Time frame
Pain. Timepoint: Every 15 minutes in recovery. Method of measurement: Visual analogue scale(VAS) as (0= non to 10= severe and unbearable pain).;Severity of postoperative nausea and vomiting. Timepoint: Every 15 minutes in recovery. Method of measurement: Scoring by (0=non, 1=nausea, 2=vomiting, 3=vomiting >2 times).;Severity of shivering. Timepoint: Every 15 minutes in recovery. Method of measurement: Observe and record the severity (shivering grade) and duration of shivering.	—

Measure

Time frame

Pain. Timepoint: Every 15 minutes in recovery. Method of measurement: Visual analogue scale(VAS) as (0= non to 10= severe and unbearable pain).;Severity of postoperative nausea and vomiting. Timepoint: Every 15 minutes in recovery. Method of measurement: Scoring by (0=non, 1=nausea, 2=vomiting, 3=vomiting >2 times).;Severity of shivering. Timepoint: Every 15 minutes in recovery. Method of measurement: Observe and record the severity (shivering grade) and duration of shivering.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBahman Naghipour

Tabriz University of Medical Sciences

naghipourb@tbzmed.ac.ir+98 41 3334 1994

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026