Comparison effect of Azithromycin and Amoxiclave in treatment of acute sinusitis.

A comparsion of efficacy and safety of Azithromycin and Amoxicillin-Clavulante in the treatement of acute bacterial sinusitis in adults.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201401046252N5

Enrollment

Registered

2014-02-11

Start date

2013-04-04

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sinusitis. Diseases of respiratory system

Interventions

Intervention 1: In first group Azithromycin was administered 500mg daily for three days. Intervention 2: In second group Amoxicillin-Clavulante was administered 625mg three times daily for ten days.

Treatment - Drugs

In first group Azithromycin was administered 500mg daily for three days.

In second group Amoxicillin-Clavulante was administered 625mg three times daily for ten days.

Eligibility

Sex/Gender

All

Age

12 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:Having at least two major or one major and two minor sinusitis criterias that have lasted 7to28days. Major criterias included: pain or feeling of fullness in face; nasal obstruction; nasal or postnasal discharge; anosmia or hyposmia; fever. Minor criterias included: headache; halitosis; fatigue; toothache; cough; otalgia or feeling of fullness in the ears. Exclusion criterias: choronic sinusitis; recurrent sinusitis; anatomic deformitis(severe septal deviation; cleft palate); choronic disease(hepatic; renal; cardiac and ashtma); pregnancy and breast feeding; allergy to drugs; cilliary dysfunction; cystic fibrosis; HIV infection; diabetes; using of steroid; complication of sinusitis like orbital cellulitis; using of antibiotics in last 30 days; having less12 years old or more than 65 years old.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Facial pain. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Nasal obstruction. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Nasal or postnasal discharge. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Anosmia or hyposmia. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Fever. Timepoint: First day- fifth day- tenth day. Method of measurement: With termometer.	—

Measure

Time frame

Facial pain. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Nasal obstruction. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Nasal or postnasal discharge. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Anosmia or hyposmia. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Fever. Timepoint: First day- fifth day- tenth day. Method of measurement: With termometer.

—

Secondary

Measure	Time frame
Headache. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Halitosis. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Fatigue. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Toothache. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Cough. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Otalgia or feeling of fullness in ears. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Diarrhea. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Vomiting. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.	—

Measure

Time frame

Headache. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Halitosis. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Fatigue. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Toothache. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Cough. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Otalgia or feeling of fullness in ears. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Diarrhea. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.;Vomiting. Timepoint: First day- fifth day- tenth day. Method of measurement: Visual.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoroush Amani MD

Shahrekord Unhversity of Medical Sciences

info@Skums.ac.ir+98 38 1333 0061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026