Condition 1: low birth weight. Condition 2: hyperbilirubinemia. Other low birth weight Neonatal jaundice associated with preterm delivery
Conditions
Interventions
Intervention 1: in cases: zinc sulfate 10 mg BID as per oral for 5 days or placebo twice time/ day. Intervention 2: in controls:Placebo.
Treatment - Drugs
Placebo
in cases: zinc sulfate 10 mg BID as per oral for 5 days or placebo twice time/ day
in controls:Placebo
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
2 Days to 28 Days
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Babies who admitted to NICU of Imam Reza Hospital; birth weight 1500-2500 gm; Exclusion Criteria: jaundice in day one; hemolysis with positive comb’s test; severely ill babies; infection and sepsis based on clinical and lab test; those with ventilator support; five minutes apgar less than 7; congenital anomalies; intolerance of feeding ; intolerance of zinc supplementation ( gastrointestinal hemorrhage and residue, suddenly getting poor general condition) ; and mothers with sing of high or low level of serum zinc
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreasing of serum bilirubin. Timepoint: befor intervention and 12,24,48,72 , 96 and 120 hours after intervention. Method of measurement: measurment of serum bilirubin (diazo method). | — |
Secondary
| Measure | Time frame |
|---|---|
| Tereatment of jaundice of neonate. Timepoint: befor intervention and 24,48,72 , 96 and 120 hours after intervention. Method of measurement: decreasing of jaundice and bilirubin level in blood serum. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Ashraf Mohammadzadeh
Neonatal Research Center
Outcome results
None listed