gestational diabetes. Diabetes mellitus in pregnancy, unspecified
Conditions
Interventions
Intervention 1: In the metformin group, the treatment will begin with 500 mg of metformin (produced by Apotex company, holding the trademark
Apo Metfromin). It will be given once or twice a day starting with meals so that within a 1 to 2 week’s time the target blood glucose is reached or to the maximum level of 2500 mg of daily dosage it w
Treatment - Drugs
In the metformin group, the treatment will begin with 500 mg of metformin (produced by Apotex company, holding the trademark
Insulin will be used in a 0.5 to 1 unit/kg dosage dependent on the pregnancy age (in the 1st trimester: 0.5 unit/kg, 2nd trimester: 0.7 unit/kg and the 3rd trimester: 1 unit/kg). According to the Mult
Sponsors
Vice Chancellor for Research and Technology, Hormozgan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age ranging from 18 to 45; affliction with gestational diabetes according to the criteria pinpointed by Australian Diabetes in Pregnancy Society (ADIPS); pregnancy with a single embryo; 20th to 32th week of pregnancy; meeting the hospital’s common criteria concerning the beginning of insulin (after the diet intervention and physical exercises their capillary blood glucose after an overnight fast should be above 90 mg/dl or their 2hpp blood glucose measurement should be above 120.6 d.l.). Exclusion criteria: pre-pregnancy diabetes; metformin consumption; embryonic anomaly; hypertensive pregnancy disorders; pre-eclampsia; embryonic growth restriction and premature rupture.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maternal blood glucose control. Timepoint: During pregnancy: every 2 weeks. Method of measurement: During pregnancy: every 2 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| Birth weight. Timepoint: 2 hour after delivery. Method of measurement: Neonatal weight measurement.;Birth height. Timepoint: 2 hour after delivery. Method of measurement: Baby Height gauges.;Head circumference. Timepoint: 2 hour after delivery. Method of measurement: With using meter.;Chest circumference. Timepoint: 2 hour after delivery. Method of measurement: With using meter.;First minute apgar. Timepoint: One minute after delivery. Method of measurement: Apgar score.;Fiftt minute apgar. Timepoint: Five minutes after delivery. Method of measurement: Apgar score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mojgan Rahbar
Hormozgan University of Medical Sciences
Outcome results
None listed