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Effect of dorzolamide drop with intravitreal avastin injection in decreasing central macular thickness

Effect of dorzolamide drop with intravitreal avastin injection in decreasing central macular thickness in diabetic patient with diabetic macular edema

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20131229015975N5
Enrollment
16
Registered
2019-09-05
Start date
2017-09-23
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Edema macula. Other specified disorders of eye and adnexa in diseases classified elsewhere

Interventions

Intervention 1: Intervention group: 16 diabetic patients with elevated double-walled macular thickness in one eye randomly selected in addition to intravascular injection of Avastin at baseline and 1

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 62 Years

Inclusion criteria

Inclusion criteria: Diabetic patients with retinopathy who have macular edema due to increased macular thickness or vision loss are indicative of anti-VEGF treatment. A transparent mediator for a thorough examination Visual activity of both eyes are better than 1/10 and less than 4/10 Patient consent to Participate in the Study The thickness of the central area of the macula at the start of treatment is greater than 300 microns

Exclusion criteria

Exclusion criteria: History of bone surgery The presence of atrophy, scarring, fibrosis and hard exudates in the macular center that affects visual acuity. Uncontrolled blood pressure Presence of active eye infectious disease There are other complications of diabetes in the eyes, which leads to an increase in the thickness of the macula. The presence of other synchronous eye pathologies such as glaucoma and cataracts.

Design outcomes

Primary

MeasureTime frame
Visual activity. Timepoint: Before and two months after the intervention. Method of measurement: Examination by ophthalmologist.;Foie thickness. Timepoint: Before and two months after the intervention. Method of measurement: Optical Coherence Topography and Examination by ophthalmologist.;Macular volume. Timepoint: Before and two months after the intervention. Method of measurement: Optical Coherence Topography and Examination by ophthalmologist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohsen Pourazizi

Esfahan University of Medical Sciences

m.pourazizi@yahoo.com+98 31 3445 2031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 19, 2026