Investigating the association between clinical and ocular characteristics with the outcomes of corneal collagen cross-linking (CXL)

Investigating the association between clinical and ocular characteristics with the outcomes of corneal collagen cross-linking (CXL) in patients with keratoconus (KC)

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20131229015975N4

Enrollment

Registered

2019-05-02

Start date

2017-08-23

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus. Keratoconus

Interventions

Intervention group: 85 patients with keratoconus, underwent corneal cross-collagen surgery to improve the patient's vision and prevent disease progression. Visual acuity, intraocular pressure, and tea

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient satisfaction keratoconus patients who are newly candidates for corneal collagen cross-linking

Exclusion criteria

Exclusion criteria: Patients who have any of the following concomitant ocular diseases: diabetic macular edema, age-related macular degeneration. other corneal diseases pregnancy, and breastfeeding period

Design outcomes

Primary

Measure	Time frame
Visual acuity. Timepoint: Before surgery and six months after surgery. Method of measurement: Snellen chart.;Corneal power. Timepoint: Before surgery and six months after surgery. Method of measurement: Pentacam imaging.	—

Secondary

Measure	Time frame
Levels of tear biomarkers. Timepoint: Before surgery and six months after surgery. Method of measurement: The lab using ELISA TEAR IL6 and Tear TNF-a tests.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Pourazizi

Esfahan University of Medical Sciences

m.pourazizi@yahoo.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026