Condition 1: Overweight and obesity. Condition 2: depression. Overweight and obesity Major depressive disorder, single episode, mild
Conditions
Interventions
Intervention 1: Intervention group: daily intake of 3 g sumac powder as 3 capsules of 1000 mg before each meals with weight reduction diet for 12 weeks. Intervention 2: Control group: daily intake of
Sponsors
Vice chancellor for research, Shahid Beheshti University of Medical sciences- School of Nutrition
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Female gender Willingness to cooperate Age 20-65 years Body mass index above 24/9 kg/m2 Mild to moderate depression
Exclusion criteria
Exclusion criteria: Use of anti-inflammation drugs (Steroids and non steroids) Continuous use (more than once a week) of vitamin and mineral supplements with anti-inflammatory and antioxidant properties such as omega-3, vitamin E in the past month Use of weight loss and appetite suppressants Use of antidepressants Diabetes Cases of various autoimmune inflammatory diseases such as multiple sclerosis, rheumatoid arthritis and ... Acute gastrointestinal disease (gastric ulcer, bowel disease, etc.) Chronic kidney or liver disease, with the exception of non-alcoholic fatty liver Infectious diseases up to 1 month before the start of the study Acute mental disorders, Bipolar Disorders, Schizophrenia Weight loss diet in one months ago Surgery in a recent month Sensitivity to sumac Pregnancy Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body weight. Timepoint: before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: seca scale.;Body Mass Index. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: calculation (kg/m2).;Waist Circumference. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: Meter strip.;Hip circumference. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: Meter strip.;Waist circumference to hip ratio. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: Calculation.;Body fat percentage. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: Body Analyzer.;Visceral fat. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of interventionbefore intervention. Method of measurement: Body Analyzer.;Body fat free mass. Timepoint: Before intervention, after 6 weeks of intervention and after 12 weeks of intervention. Method of measurement: Body Analyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum concentration of insulin. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: ELISA.;Malondialdehyde. Timepoint: Before intervention and after 12 weeks of intervention. Method of measurement: ELISA.;Serum concentration of Leptin. Timepoint: Before intervention and after 12 weeks of intervention. Method of measurement: ELISA.;Serum concentration of Neuropeptide Y. Timepoint: Before intervention and after 12 weeks of intervention. Method of measurement: ELISA.;Serum concentration of hs-CRP. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: ELISA.;Serum concentration of TNF-alpha. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: ELISA.;Serum concentration of IL-6. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: ELISA.;Serum concentration of glucose. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: Enzymatic method.;Serum concentration of triglyceride. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: Enzymatic method.;Serum concentration of total cholesterol. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: Enzymatic method.;Serum concentration of High Density Lipoprotein. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: Enzymatic method.;Serum concentration of low density lipoprotein. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: Enzymatic method.;HOMA-IR. Timepoint: calculation ([Glucose (mg/dl)]*[Insulin]/405). Method of measurement: Before intervention, twelve weeks after intervention.;Appetite. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: simple appetite questionnaire.;Depression. Timepoint: Before intervention, twelve weeks after intervention. Method of measurement: Bec | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNastaran Hariri
Shahid Beheshti University of Medical sciences- School of Nutrition
Outcome results
None listed