Brain-Derived Neurotrophic Factor level in Depressive patients

Evaluation of the effectc of the synchronised exercise and electroconvalsive therapy on serum brain neurotherupic factor in drug resistance depressive patient

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201312271743N12

Enrollment

Registered

2014-01-07

Start date

2013-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Depressive episode

Interventions

Intervention 1: Electero Convulsive Therapy+ antidepressant drug. Intervention 2: exercise +antidepressant. Intervention 3: Antidepressant drug.

Treatment - Drugs

Electero Convulsive Therapy+ antidepressant drug

exercise +antidepressant

Antidepressant drug

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusive Criteria 1. Patients with unipolar major depressive disorder admitted in one of the psychiatric wards of Farshchian Hospital 2. Aged of 18-40 years 3. No systemic diseases such as diabetes, hypertension, epilepsy and etc 4. No history of alcohol abuse or other illegal substances 5. Patient’s informed consent Exclusive Criteria 1. Incidence of uncontrollable somatic condition 2. Patient’s unwillingness to continue participation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Severity of symptoms of Depression. Timepoint: Baseline and 4 weeks after treatment. Method of measurement: Hamiltone Depression scale.;Level of Brain-derived neurotrophic factor in serum. Timepoint: Baseline and 4 weeks after treatment. Method of measurement: ELISA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Haghighi

Research center for behavioral disorders and substance abuse, Hamadan university of medical sciences

haghighi@umsha.ac.ir+98 81 1827 1066

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026