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Is oral tranexamic acid effective in reduction of blood loss during rhinoplasty?

Effect of preoperative oral tranexamic acid on intraoperative bleeding during rhinoplasty: A Clinical Trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201312271674N10
Enrollment
50
Registered
2014-04-12
Start date
2014-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty. 00

Interventions

Intervention 1: Drug is administered with dose of 1000 mg (two 500 mg tablets) orally with about 20 cc of water are given to the patient's study 2 hours before surgery. Intervention 2: The second
Treatment - Drugs
Drug is administered with dose of 1000 mg (two 500 mg tablets) orally with about 20 cc of water are given to the patient's study 2 hours before surgery.
The second group or control group received placebo with about 20 cc of water 2 hours before surgery.

Sponsors

Vice-Chancellery of Research and Technology, Shiraz University Of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included: The patients with systemic disease and no history of drug use, and willingness to cooperate in this study are enrolled? Exclusion criteria included known allergy to the study drug, hepatic and renal dysfunction and lack of signed informed consent will be excluded.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
The amount of intraoperative bleeding. Timepoint: End of surgery. Method of measurement: Weight of the Gauze in the operating room for surgery with digital scale.;Blood pressure and heart rate values. Timepoint: Preoperative, intraoperative and postoperative. Method of measurement: Vital signs monitoring device.

Secondary

MeasureTime frame
Side effects of postoperative oral tranexamic acid. Timepoint: Postoperative in recovery room. Method of measurement: The nurse reported in the recovery.;Agitation and postoperative shivering. Timepoint: Recovery room. Method of measurement: The nurse reported in the recovery.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Reza Eftekharian

Shiraz University Of Medical Sciences

eftekharhr@sums.ac.ir+98 71 1648 3783

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 3, 2026