Skip to content

The evaluation of the priming effect of transcranial direct current stimulation over primary motor cortex and primary somatosensory cortex on the effect of exercise training on pain, function, balance, kinesiophobia and quality of life in patients with knee osteoarthritis-a randomized controlled trial

The evaluation of the priming effect of transcranial direct current stimulation over primary motor cortex and primary somatosensory cortex on the effect of exercise training on pain, function, balance , kinesiophobia and quality of life in patients with knee osteoarthritis-a randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20131225015932N18
Enrollment
45
Registered
2023-02-10
Start date
2023-04-04
Completion date
Unknown
Last updated
2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Control group: Exercise therapy and placebo tDCS. Intervention 2: Intervention group: Exercise therapy and anodal tDCS on M1. Intervention 3: Intervention group: Exercise therapy and c

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Diagnosis of osteoarthritis in one or both knees by an orthopedic specialist for these patients (having at least three of the six criteria of the American College of Rheumatology, including age over 50 years, morning stiffness less than half an hour, tenderness in bone margins, crepitus in active joint movements, bone enlargement and no palpable increase in temperature People aged 50 to 70 who are willing and eager to enter the study and can cooperate in various stages of evaluation, treatment and follow-up Grade two or three of diseases in the knee osteoarthritis classification system (Kllgren and Lawrence system classification) according to a radiograph that was taken at most one year ago minimum pain intensity of four out of ten (while walking in the last week) in Visual analogue scale of pain.

Exclusion criteria

Exclusion criteria: Traumatic knee injuries Acute joint inflammation Rheumatology diseases such as Rheumatoid arthritis, lupus erythematosus and Fibromyalgia, Neurological diseases that affect the function of the lower limbs, such as stroke, Parkinson's disease, MS, peripheral neuropathy and a history of seizures or their occurrence, severe headaches after the first session of receiving the electrical current, mental and cognitive problems (Mini-Mental Status Exam score = 23),Cardiovascular problems such as high blood pressure or heart attack History of surgery (such as joint replacement or tibial osteotomy) in one or both knees, history of head surgery, Brain tumor or metal implant in the head, history of lower limb surgery in the last six months Inability to walk without an assistive device, receiving treatment or rehabilitation services for knee osteoarthritis in the last three months Taking drugs that affect the central nervous system such as dextromethorphan and D-cycloserine in the last six months Drug or alcohol abuse Being hospitalized for the past year due to mental illnesses

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Before treatment, third week of treatment, fourth week of treatment and one month after treatment. Method of measurement: Visual analogue scale.;Balance. Timepoint: Before treatment, third week of treatment, fourth week of treatment and one month after treatment. Method of measurement: Modified star excursion balance test.;Quality of life. Timepoint: Before treatment, third week of treatment, fourth week of treatment and one month after treatment. Method of measurement: SF36 questionnaire.;Kinesiophobia. Timepoint: Before treatment, third week of treatment, fourth week of treatment and one month after treatment. Method of measurement: Tampa scale.;Function. Timepoint: Before treatment, third week of treatment, fourth week of treatment and one month after treatment. Method of measurement: WOMAC.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmin Rastgar sangari

Shiraz University of Medical Sciences

rastgar.amin@yahoo.com00 71 3336 1081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026