effects of L-carnitine on kidneyl graft function

Evaluation of protective effects of L-carnitine on the delayed graft function(DGF) in kidney transplant recipients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201312233043N9

Enrollment

Registered

2014-02-10

Start date

2014-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney transplantation. Kidney transplant failure and rejection

Interventions

Intervention 1: L-carnitine syrup(500mg/5ml), 3000mg (30ml) day before transplantation and 3000 mg(30ml)(divided in 3 doses) daily for 3 day after transplantation. Intervention 2: placebo syrup 30ml,d

Treatment - Drugs

L-carnitine syrup(500mg/5ml), 3000mg (30ml) day before transplantation and 3000 mg(30ml)(divided in 3 doses) daily for 3 day after transplantation

placebo syrup 30ml,day before transplantation and 30 ml (in three divided doses) daily for 3 days after transplantation

Eligibility

Sex/Gender

All

Age

14 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 1. Subjects who are planned to recieve kidney transplantation 2. Subjects of 14-70 years old Exclusion Criteria: 1. Intercurrent acute and severe infections eg: septic shock, myocarditis, acute pancreatitis 2. History of allergy to carnitine or its analogues 3. History of seizure or at high risk for seizure 4. Intercurrent cardiac/hepatic/pulmonary instability during few days after transplantation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Plasma NGAL level. Timepoint: baseline and 2,6,12, 24 and 96 hours after transplantation. Method of measurement: ELISA.;Plasma carnitine level. Timepoint: baseline and 96 hours after transplantation. Method of measurement: ELISA.;Delayed graft function. Timepoint: during first week after transplantation. Method of measurement: Scr, urine output, need for dialysis.	—

Secondary

Measure	Time frame
Serum sodium concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: ISE.;Serum creatinine concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: Jaffe method.;Acute rejection during 2 months after transplantation. Timepoint: during first and second month. Method of measurement: serum creatinine.;Serum potassium concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: ISE.	—

Measure

Time frame

Serum sodium concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: ISE.;Serum creatinine concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: Jaffe method.;Acute rejection during 2 months after transplantation. Timepoint: during first and second month. Method of measurement: serum creatinine.;Serum potassium concentration. Timepoint: at baseline and daily up to day 7 after transplantation. Method of measurement: ISE.

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026