lichen planus. Other lichen planus
Conditions
Interventions
In this study, in the first week, 7.5 mg methotraxate per week (three tablets, 2.5 milligrams) plus 1mg folic acid per day will be administered and from the next week, 15 mg per week plus 1mg folic ac
Treatment - Drugs
Sponsors
Tehran University Of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with oral lichen planus, diagnosed by clinical and pathological criteria, who did not respond to topical therapy. Exclusion criteria: Pregnancy and breast feeding; cancer; severe and frequent infections; Hereditary or acquired immunodeficiency; leukopenia; anemia; thrombocytopenia; hepatic dysfunction; Stomach ulcers; dysplastic lesions in pathology; ulcerative colitis disease; side effects of methotraxate
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The resolution of oral lesions. Timepoint: Before treatment and at two, four, eight and twelve weeks. Method of measurement: Thongprasom Scale.;Pain reduction. Timepoint: Before treatment and at weeks two, four, eight and twelve. Method of measurement: VAS ( Visual Analog Scale) Pain was scored from zero to ten. | — |
Secondary
| Measure | Time frame |
|---|---|
| The side effects of methotraxate. Timepoint: First, fourth, eighth and twelfth week. Method of measurement: Examination in each visit.;The Size of lesions. Timepoint: First, fourth, eighth and twelfth week. Method of measurement: Transparent grid ( mm ).;Duration of disease since diagnosis. Timepoint: Before treatment. Method of measurement: Interview.;The type of lesion (ulcerative , reticular , atrophic). Timepoint: Before treatment. Method of measurement: previous records.;The location of lesions (bucal , gingival , palatine). Timepoint: Before treatment. Method of measurement: previous records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Shafiee
Razi Hospital
Outcome results
None listed