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Efficacy evaluation of pomegranate peel extract in oral candidiasis treatment

Comparison of Pomegranate peel extract anticandidal activity and nystatin in patients with oral candidiasis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT201312161059N2
Enrollment
60
Registered
2014-05-11
Start date
2014-06-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Candidiasis. Candidal stomatitis/Oral thrush

Interventions

Intervention 1: Intervention 1: Pomegranate (Punica granatum L.) peel extract gel. The oral gel contains pomegranate peel extract. It will be prepare in Jaber Ebne Hayyan Pharmaceutical Company in 4
Treatment - Drugs
Intervention 1: Pomegranate (Punica granatum L.) peel extract gel. The oral gel contains pomegranate peel extract. It will be prepare in Jaber Ebne Hayyan Pharmaceutical Company in 40 ml tubes and i
Intervention 2: Nystatin The nystatin level is 1.72% w/w. The combination of carbopol and hydroxypropyl methylcellulose will be used as a gel vehicle for nystatin topical application. It will be pr

Sponsors

Science Medical Vice chancellor for research, Pasteur Institute of Iran
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: The patients who have oral candidiasis. Exclusion criteria: The patients who unable to provide informed consent, may not adhere to treatment or may not complete follow up.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Presence of fungal infections. Timepoint: before intervention, one week after intervention and end of intervention. Method of measurement: Clinical examinations of oral lesion, fungal laboratory direct and culture examination of oral lesion.

Secondary

MeasureTime frame
Presence of side effect. Timepoint: One week and two weeks after intervention. Method of measurement: Clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahindokht Bassiri-Jahromi

Pasteur Institute of Iran

basiri@pasteur.ac.ir; bassirishahindokht@yahoo.com+98 21 6695 3311

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026