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The effect of premedication on tooth anesthesia

Efficacy of premedication with ibuprofen on the success of lower alveolar nerve block with lidocaine in comparison with infiltration of articaine in symptomatic irreversible pulpitis.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20131216015814N3
Enrollment
88
Registered
2018-02-21
Start date
2017-11-22
Completion date
Unknown
Last updated
2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis.

Interventions

Intervention 1: Intervention 1:Premedication with ibuprofen (400 mg) 30 minutes before anesthesia and infiltration of articaine 4% + epinephrine 1.100000. Intervention 2: Intervention 2: Premedication

Sponsors

Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients with first or second mandibular molars requiring root canal treatment with the diagnosis of symptomatic irreversible pulpitis and a history of spontaneous pain. Patients who are completely healthy or have a mild systemic disease that is well controlled (ASA I, II) Patients who have the ability to fill out a questionnaire and a consent letter Patients over 18 years old

Exclusion criteria

Exclusion criteria: Patients with heart pacemakers Asthma, coagulation disorders, immune deficiency, diabetes, hypertension, mental disorders pregnancy Sensitivity or contraindication for receiving lidocaine, articaine, epinephrine and NSAIDs The presence of open apex or calcification in the root of the Intended tooth The presence of extensive restoration or periodontal disease use of analgesic drugs 12 hours before treatment

Design outcomes

Primary

MeasureTime frame
Pain during cavity preparation. Timepoint: Fifteen minutes after injection. Method of measurement: Visual analogue scale.

Secondary

MeasureTime frame
Need for complementary injection. Timepoint: Fifteen minutes after block injection. Method of measurement: Complementary anesthetizing.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahrzad Jalali

Qazvin Dental School

Jalali.shahrzad@gmail.com+98 28 3335 3061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026