prediabetes. Abnormal glucose tolerance test
Conditions
Interventions
Intervention 1: Daily consumption of one 1000 micro grams soft gel vitamin k1 for 4 weeks in intervention group. Intervention 2: Daily consumption of one softgel placebo for 4 weeks in the control gr
Prevention
Placebo
Daily consumption of one 1000 micro grams soft gel vitamin k1 for 4 weeks in intervention group.
Daily consumption of one softgel placebo for 4 weeks in the control group.
Sponsors
Vice Chancellor For Research Of Ahvaz Jundishapur University Of Medical Science, Ahvaz Jundishapur
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Willingness to participate in the study and sign the Written informed consent; Age between 22 to 45 years old; BMI=25-29.9 kg/m2; 100 =FBS=126 or 140 =2hpp=200 mg/dL Exclusion criteria: Heart, Kidney, liver and Rheumatoid diseases; Osteoporosis; Hyperthyroidism and Thyroid dysfunction; Pregnancy; Lactation; Menopause; Intake of insulin and glucose and lipid-lowering Agents; Warfarin; Corticosteroids; drugs to treat osteoporosis; Vitamin and Mineral supplements during past 6 months.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum carboxylated osteocalcin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum carboxylated osteocalcin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum total osteocalcin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum Hb A1C. Timepoint: Baseline and after 4 weeks. Method of measurement: HPLC assay.;Total energy and nutrient intaake. Timepoint: Baseline, middle and 4th weeks. Method of measurement: 24 hour recall. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting and 2 hour serum insulin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Fasting and 2 hour serum glucose. Timepoint: Baseline and after 4 weeks. Method of measurement: calorimetric assay.;HOMA-IR. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;HOMA-%B. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;ISI. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;Serum adiponectin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;Serum leptin. Timepoint: Baseline and after 4 weeks. Method of measurement: ELISA assay.;BMI. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;Waist to hip ratio. Timepoint: Baseline and after 4 weeks. Method of measurement: formula.;Bady fat. Timepoint: Baseline and after 4 weeks. Method of measurement: OMRON. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamid Rasekhi
Ahvaz Jundishapur University of Medical Science
Outcome results
None listed