Effect of combination therapy of Methotrexate with Vitamin A , in patients with low risk GTN (Gestational Trophoblastic Neoplasia)

The effect of vitamin A on the Gestational Trophoblastic Neoplasia low risk pregnancy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013120615676N1

Enrollment

Registered

2014-12-19

Start date

2013-10-09

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational Trophoblastic Neoplasia. Carcinoma in situ of other specified sites

Interventions

Intervention 1: Intervention: pulse weekly intramuscular methotrexate weekly associated with intramuscular dose of 200,000 IU of vitamin A for 8. Intervention 2: pulse weekly intramuscular methotrexa

Treatment - Drugs

Intervention: pulse weekly intramuscular methotrexate weekly associated with intramuscular dose of 200,000 IU of vitamin A for 8

pulse weekly intramuscular methotrexate

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criterion: low risk Gestational Trophoblastic Neoplasia. Exclusion criteria: pregnancy, side effects including methotrexate and vitamin A, medical diseases (diseases of the cerebral, eye, cutaneous, liver).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Beta HCG. Timepoint: Weekly. Method of measurement: mIU/ml.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSedigheh ghasemian Dizaj Mehr

Mashhad University of Medical Sciences

ghasemians901@mums.ac.ir+98 51 3711 2488

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026