Patients with traumatic brain injury. Unspecified intracranial injury
Conditions
Interventions
Intervention 1: Patients in the first intervention group are given saffron hydroalcoholic extract syrup (100 mg per day) for 10 days.This product will be produced by the School of Persian Medicine, De
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Hospitalization for fewer than 3 days Age range between 18 and 65 years Patients with moderate to sever traumatic brain injury based on GCS index (3-12) No record of delirium, dementia, and hospitalization in psychiatric hospitals or centers No record of active bleeding or coagulation disorders, No record of allergies to saffron.
Exclusion criteria
Exclusion criteria: Children and elderly with traumatic brain injury Patients with severe traumatic brain injury Any record of non-traumatic cerebral hemorrhage Decreased level of consciousness due to metabolic disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of consciousness. Timepoint: Daily for 10 consecutive days. Method of measurement: Glasgow Coma Scale.;Cognitive Function. Timepoint: Daily for 10 consecutive days. Method of measurement: Rancho Los Amigos Level of Cognitive Functioning Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Total activities of serum antioxidant. Timepoint: Before the intervention and after 10 days. Method of measurement: The superoxide dismutase (SOD) serum activity was measured based on controlling the reduction of nitro-blue tetrazolium by the superoxide at 560 nm. The catalase (CAT) activity was determined by monitoring the initial rate of disappearance of H2O2 at 240 nm. Glutathione S-transferase (GST) activity was assayed based on monitoring the formation of the thioether product of the reaction between glutathione (GSH) and 1-chloro-2, 4-dinitrobenzene at 340 nm. GSH level was performed at 412 nm by the use of 5, 5’-dithiobis 2-nitrobenzoic acid. Serum glutathione peroxidase (GPx) and glutathione reductase (GR) activities were determined based on the decrease in absorbance of NADPH at 340 nm. The total antioxidant capacity (TAC) was measured by ferric reducing/antioxidant power (FRAP) method using commercially available kit. Malondialdehyde (MDA) level, as an indicator of lipid peroxidation, was measured as a result of condensation with thiobarbituric acid at 532 nm. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Eghbali
Torbate-Heidaria University of Medical Sciences
Outcome results
None listed