Common Migrain. Migraine without aura [common migraine]
Conditions
Interventions
Intervention 1: Caffeine 60 mg Intravenously/ slow infusion in 30 min (one time). Intervention 2: Ketorolac 60 mg Intravenously/ slow infusion in 30 min (one time).
Treatment - Drugs
Caffeine 60 mg Intravenously/ slow infusion in 30 min (one time)
Ketorolac 60 mg Intravenously/ slow infusion in 30 min (one time)
Sponsors
Shohadaye Tajrish clinical research center
Vice chancellor for research, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Moderate to sever pain(pain score>4) in ages 18-60 year old; with History of at least five attacks lasts 4 to 72 hours (untreated or unsuccessfully treated) and headache has at least two of the following characteristics:Unilateral location, Pulsating quality, Moderate to severe pain intensity, Aggravation by or causing avoidance of routine physical activity; At least one of the following during headache: Nausea or vomiting (or both), Photophobia and phonophobia; Not attributable to another disorder Exclusion criteria: History of ... Arrhythmia; Ischemic heart disease; Hypertension; Peptic ulcer disease; Inflammatory bowel disease; Obsessive disorder; Pregnancy; Breast feeding period; Homeostasis disorder; Renal failure; Hepatic failure; Sleep disorder
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: 1 and 2 hour after drug administration. Method of measurement: Visual Analog Scale (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: from starting drug administration to 2 hours after end. Method of measurement: physical exam. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mohammadmehdi Foruzanfar
Shahid Beheshti University of Medical Sciences
Outcome results
None listed