medical management of second trimester induced abortion. Medical abortion
Conditions
Interventions
Intervention 1: In intervention group misoprostol tablets is wetted with 3cc acetic acid 5% and then is inserted misoprostol 400 microgram vaginally followed by 200 microgram every 6 hours for max
Treatment - Drugs
Placebo
In intervention group misoprostol tablets is wetted with 3cc acetic acid 5% and then is inserted misoprostol 400 microgram vaginally followed by 200 microgram every 6 hours for maximum 48 hours.
In controlled group misoprostol is wetted with 3cc normal saline and then is inserted misoprostol 400 microgram vaginally followed by 200 microgram every 6 hours for maximum 48 hours.
Sponsors
Vice-Chancellor for Research, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: healthy pregnant women in their second trimester of pregnancy (14-20 weeks) with closed cervix who are candidate for therapeutic abortion and agree to participate in this clinical trial. Exclusion criteria: history of more than 2 cesarean section; history of cesarean section with uterine classic or T-shape incision; previous myomectomy; allergy to prostaglandins; severe vaginal bleeding before treatment; anemia Hb less than 7 g/dl ); coagulopathy; significant medical disorder(example, active liver disease, cardiovascular disease, renal failure, chronic adrenal failure, disorders requiring corticosteroid therapy); rupture of membrane and vaginitis.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete abortion rate at 24 and 48 hours. Timepoint: every 6 hours. Method of measurement: Questioneaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Failure rate. Timepoint: No abortions occurred in 48 hours. Method of measurement: sonography.;Side effects of drug. Timepoint: Every 6 hours. Method of measurement: Questionnaire.;Induction abortion interval from insertion of first dose of misoprostol. Timepoint: Every 6 hours. Method of measurement: hour. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNayereh Rahmati
Mahdieh Hospital
Outcome results
None listed