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Evaluation of the effect of oral sodium bicarbonate on the symptoms of overactive bladder and acidic urine

Comparison of the effect of oral sodium bicarbonate and tolterodine in women with symptoms of overactive bladder and acidic urine

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20131203015634N3
Enrollment
36
Registered
2022-02-27
Start date
2022-01-20
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

over active bladder. Overactive bladder

Interventions

Intervention 1: Intervention group: Women with acidic urine and hyperactive bladder symptoms over 18 years of age who are randomly selected and treated with sodium bicarbonate 500 twice a day by 36 pa

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients referred to the gynecology clinic included all patients over 18 years of age who voluntarily and knowingly complained of overactive bladder symptoms who had these symptoms for at least 12 weeks and received no treatment, had a frequency of more than 8 times and more than 2 times nocturia, urinary pH less than 6 and lacked of relaxation. Patients under 18 years of age, urinary pH more than 6, kidney stones, stress incontinence, history of abdominal menopause surgery, heart problems, urinary tract infections, malignancies, pelvic pain, neurogenic bladder , Use of antidepressants, anticholinergics, alphablockers, beta-3 agonists, and history of allergies to anticholinergics, sodium bicarbonate, rectocell, cystocell, and uterine prolapse, frequency Less than 8 and nocturia less than 2 in 24 hours are not included in the study.

Exclusion criteria

Exclusion criteria: If the patient does not want to continue taking. Allergic reaction to the drug. The patient becomes pregnant. Reluctance to continue cooperation in the project. They are excluded from the study.

Design outcomes

Primary

MeasureTime frame
OVER ACTIVE BLADDER SCORE POINT. Timepoint: One month after taking the drug. Method of measurement: questionnaire OAB-V8.;URINE PH. Timepoint: Before administration of tolterodine and sodium bicarbonate at the beginning of the study and one month after receiving tolterodine and sodium bicarbonate. Method of measurement: urine dipstick.;Oab-v8 questionnaire score based on score before and after receiving tolterodine and sodium bicarbonate. Timepoint: Before administration of tolterodine and sodium bicarbonate at the beginning of the study and one month after receiving tolterodine and sodium bicarbonate. Method of measurement: Scoring based on the score of the questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTayebeh Jahed Bozorgan

Shahid Beheshti University of Medical Sciences

tayebe.jahed@sbmu.ac.ir+98 21 5506 6263

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 11, 2026