Laparoscopic cholecystectomy. Calculus of gallbladder without cholecystitis
Conditions
Interventions
Intervention 1: In Intervention group: Patients received 0.2 mg oral Clonidine (CLONIDINE HCL 0.2MG TAB, Toliddaru, Iran) preoperatively. Intervention 2: In Placebo Group: Patients received placebo ta
Prevention
Placebo
In Intervention group: Patients received 0.2 mg oral Clonidine (CLONIDINE HCL 0.2MG TAB, Toliddaru, Iran) preoperatively.
In Placebo Group: Patients received placebo tablets in the same shape of the clonidine tablets preoperatively.
Sponsors
Research deputy, Iran University of Medical Siences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: ASA grades II and III, both males and females, adult patients aged 18 to 65 years, with Controlled Hypertension (Systolic less than 140 and diastolic less than 90) scheduled Laparoscopic cholecystectomy surgeries. Exclusion criteria: Lack of patient consent, history of bronchial asthma, patients allergic to clonidine, hypertensive and diabetic patients, severe coronary insufficiency, recent myocardial infection, concomitant use of monoamine oxidase inhibitors, tricyclic antidepressants or opioids.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial blood pressure. Timepoint: Before induction, in 1,5,10,15 and 20 minute after induction, and every 15 minute until the end of the operation. Method of measurement: Will be recorded by Automatic Hemodynamic Monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient's pain intensity. Timepoint: Entrance to the recovery, 30, 60, 90 and 120 minutes postoperatively. Method of measurement: According to VAS rating score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Reza Ghodraty MD.
Iran University of Medical Sciences
Outcome results
None listed