Comparison The Efficacy of Iranian Traditional Aloe Vera based Formula and Poly Ethylene Glycol on adult functional constipation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013112915584N1

Enrollment

Registered

2014-03-01

Start date

2013-12-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Functional chronic constipation. Constipation

Interventions

Intervention 1: Intervention group 1: Iranian traditional Aloe Vera Based formula, cap: 500 mg, 1-2 cap before sleeping with 1 glass of hot water, during 14 days. Intervention 2: Intervention group 2:

Treatment - Drugs

Intervention group 1: Iranian traditional Aloe Vera Based formula, cap: 500 mg, 1-2 cap before sleeping with 1 glass of hot water, during 14 days

Intervention group 2: Poly Ethylene Glycol powder, 15 - 20 gr with 1 glass of water/juice, 1 hour after breakfast meal, during 14 days

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age more than 18 years; have chronic functional constipation based on ROM III criteria. Exclusion criteria: Drug induced constipation; Intestinal mechanical or pseudo obstruction; Metabolic & Endocrine disorders; Pregnancy & Lactation; Neurologic & myopathic disorders; IBS; Malignancy; Previous history of GI surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Frequency of defecation per week. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Fecal shape & consistency. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Defecation time after drug consumption. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Sensation of incomplete evacuation. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Straining during defecations. Timepoint: 0: before intervention, 14: 14 days after using drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Manual maneuvers to facilitate defecations. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.	—

Measure

Time frame

Frequency of defecation per week. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Fecal shape & consistency. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Defecation time after drug consumption. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Sensation of incomplete evacuation. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Straining during defecations. Timepoint: 0: before intervention, 14: 14 days after using drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.;Manual maneuvers to facilitate defecations. Timepoint: 0:Before intervention, 14: 14 days after consuming drug, 28: 14 days without any drug (off period). Method of measurement: Questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAssie Jokar

Tehran University of Medical Sciences

arezoo2003dr@gmail.com+98 151223301216

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026