Metabolic Syndrome. Hyperglycaemia, unspecified
Conditions
Interventions
Intervention 1: Intervention group : Grape Seed Extract capsules 100 mg once daily for 8 weeks. Intervention 2: daily supplementation with placebo capsules for 8 weeks.
Treatment - Drugs
Placebo
Intervention group : Grape Seed Extract capsules 100 mg once daily for 8 weeks
daily supplementation with placebo capsules for 8 weeks
Sponsors
Nutrition Research Center,Tabriz University of Medical
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Adolescents aged 13-19 years;waist circumference (WC) above the 90th percentile in adolescents under 16 years old and WC more than 95 centimeter in adolescents over 16 years old plus 2 or more of the following items; HDL<40 mg/dL ( In teenage girls over 16 years old:HDL<50 mg/dL ) ; TG = 150mg/dL; Fasting blood glucose = 100 mg/dL; Systolic blood pressure = 130 mmHg; Diastolic blood pressure = 85mmHg Exclusion criteria: Suffering from heart disease ; Kidney disease ; Liver disease ; Hyperthyroidism or hypothyroidism; The use of anti-inflammatory drugs; smoking; Triglycerides above 500 mg per deciliter; Pregnancy in teenage girls ; The use of antioxidant supplements in the past three months; The use anticoagulant drugs , including aspirin , warfarin; Sensitivity to grapes
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lipid profile (LDL, HDL, TG). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Enzymatic methods and Friedewald formula.;Fasting Blood Glucose. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Measurement of fasting blood glucose by using kits.;HbA1c. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Using ion exchange chromatography.;Fasting Plasma Insulin. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Elisa.;Anthropometric Indices (weight , height, waist circumference , BMI). Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Using stadiometer, scale and tape.;Blood Pressure. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Mercury sphygmomanometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adiponectin. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Elisa kits.;Resistin. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Elisa kits. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed