Effect of Dexamethasone on the success of local anesthesia during root canal treatment

The effect of premedication with oral Dexamethasone on the success of inferior alveolar nerve block for teeth with irreversible pulpitis: A double blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013112515540N1

Enrollment

100

Registered

2013-12-26

Start date

2014-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis. Diseases of pulp and periapical tissues

Interventions

Intervention 1: Premedication with single dose oral dexamethasone (0.5 mg), one hour before endodontic procedure. Intervention 2: Premedication with single dose placebo (dextrose gelatin capsule), one

Treatment - Drugs

Placebo

Premedication with single dose oral dexamethasone (0.5 mg), one hour before endodontic procedure.

Premedication with single dose placebo (dextrose gelatin capsule), one hour before endodontic procedure.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Major inclusion criteria; patient with the diagnosis of symptomatic irreversible pulpitis of a posterior mandibular tooth; patients who read and sign the informed consent. Major exclusion criteria; presence of systemic disorder; sensitivity to lidocaine or SAIDs; pregnancy; lactation; history of gastrointestinal ulcer; history of using pain medications 12 hours before the endodontic procedure.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain during root canal treatment. Timepoint: during treatment. Method of measurement: visual analogue scale (VAS), which consists of a 10-cm line anchored by 2 extremes, "no pain" and "pain as bad as it could be".	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNima Moradi Majd

Qazvin university of medical sciences

nimamajd@yahoo.com+98 28 1335 3061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026