Condition 1: burns. Condition 2: burns. Condition 3: burns. Burn and corrosion of trunk Burn and corrosion of shoulder and upper limb, except wrist and hand Burn and corrosion of lower limb, except ankle and foot
Conditions
Interventions
Intervention 1: Intervention group 1: hydrolyzed collagen alone ( 40 gr daily + 9 ml sunflower oil ). Intervention 2: Intervention group 2 : hydrolyzed collagen in combination with fish oil ( 40 gr da
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Burns of 20-45% of body surface area Degree 2 (deep) or 3 18-60 years old men and women The ability to oral intake up to 48 hours after admission
Exclusion criteria
Exclusion criteria: Past medical history of diabetes and other endocrine disorders, cancer , digestive disorders and malabsorption , cardiovascular and respiratory diseases, organ failure such as liver and kidney failure , infectious diseases, and autoimmune disease History of allergy or intolerance to protein products Pregnant or postmenopausal women Smoking , addiction , alcohol cosumption Taking NSAIDs and anticoagulant medications Taking high doses of protein or omega-3 fatty acid supplements within 3 months prior to study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination and comparison of gut Lactobacillus between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.;Determination and comparison of gut Enterobacteriaceae between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.;Determination and comparison of gut Bifidobacterium between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR.;Determination and comparison of gut Firmicutes / Bacteroidetes ratio between 3 study groups. Timepoint: before and after 2 weeks of intervention. Method of measurement: Real Time PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShiva Salehi
Tehran University of Medical Sciences
Outcome results
None listed