The effect of Alpha-lipoic acid supplement in patients undergoing coronary artery bypass surgery

Effect of alpha-lipoic acid supplementation on atrial fibrillation and biomarkers of myocardial injury in patients undergoing coronary artery bypass surgery: Study protocol of a randomized, double-blind, placebo-controlled clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20131125015536N16

Enrollment

Registered

2024-11-14

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass surgery. Atherosclerosis of coronary artery bypass graft(s), unspecified, with angina pectoris

Interventions

Intervention 1: Intervention group: This intervention is performed on each patient within 15 days, 10 days before surgery and 5 days after surgery. The selected dose for Alpha-lipoic acid supplement i

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Candidate patients for On-Pump CABG with cardiac arrest with or without valve replacement Patients in the age range of 40-70 years

Exclusion criteria

Exclusion criteria: History of severe renal failure (GFR 8%) with medication through history and checking the patient's last test Patients with congenital heart disease and its investigation through patient records and history History of taking Omega 3 supplement 1 month before surgery and checking it through patient file and history The history of taking any antioxidant supplement 1 month before surgery and checking it through the patient's file and history Active gastrointestinal bleeding and checking it through bloody vomiting or bloody stools The history of corticosteroid use during the last 1 month and its review through the patient file and history Unwillingness to cooperate and enter the study

Design outcomes

Primary

Measure	Time frame
Creatine kinase- Myocardial Bind. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Troponin I. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Post operative atrial fibrillation. Timepoint: Daily up to 5 days after surgery through Holter 72 hours in the first 3 days and then from day 4 to 5 through ECG 3 times a day. Method of measurement: Holter 72 hours and ECG.;Length of hospital stay. Timepoint: Until discharge. Method of measurement: Patient file.;Length of ICU stay. Timepoint: Until discharge. Method of measurement: Patient file.;Echocardiographic indicators (LVEF ? EAT). Timepoint: 10 days before surgery and 5 days after surgery. Method of measurement: Echocardiography.;Nutritional status assessment. Timepoint: During the 15 days of study every 3 days. Method of measurement: 24 hours recall.	—

Measure

Time frame

Creatine kinase- Myocardial Bind. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Troponin I. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Post operative atrial fibrillation. Timepoint: Daily up to 5 days after surgery through Holter 72 hours in the first 3 days and then from day 4 to 5 through ECG 3 times a day. Method of measurement: Holter 72 hours and ECG.;Length of hospital stay. Timepoint: Until discharge. Method of measurement: Patient file.;Length of ICU stay. Timepoint: Until discharge. Method of measurement: Patient file.;Echocardiographic indicators (LVEF ? EAT). Timepoint: 10 days before surgery and 5 days after surgery. Method of measurement: Echocardiography.;Nutritional status assessment. Timepoint: During the 15 days of study every 3 days. Method of measurement: 24 hours recall.

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Secondary

Measure	Time frame
Total protein. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Albumin. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Erythrocyte sedimentation rate (ESR). Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;C-reactive protein (CRP). Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.	—

Measure

Time frame

Total protein. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Albumin. Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;Erythrocyte sedimentation rate (ESR). Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.;C-reactive protein (CRP). Timepoint: 10 days before surgery, 24 hours after surgery and 5 days after surgery. Method of measurement: Blood sampling.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Javad Hosseinzadeh

Tehran University of Medical Sciences

Mhosseinzadeh@tums.ac.ir+98 21 8899 3059

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Aug 20, 2026