Depression. Major depressive disorder, single episode, moderate
Conditions
Interventions
Intervention 1: Intervention group: modified psychobiotic diet It uses foods that have effects on beneficial intestinal bacteria in the gut brain axis. 6 t
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Have mild to moderate depression 18-65 years old BMI 25-35
Exclusion criteria
Exclusion criteria: Have any special diet Receiving antioxidant or omega 3 supplements within 6 weeks before starting the intervention Taking psychotropic drugs, contraceptives, antibiotics, proton pump inhibitors, steroids, immunosuppressive drugs, and laxatives up to four weeks before the intervention. Non-steroidal anti-inflammatory drugs > dose of 3 grams History of kidney, liver, heart or respiratory disease, heart attack or stroke Functional problems of the digestive system, chronic constipation Smoking or tobacco use Pregnancy and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score in Beck Questionnaire. Timepoint: Measurement of the depression score at the beginning of the study (before the start of the intervention) and 6 weeks after the start of the modified psychobiotic diet. Method of measurement: Beck Depression questionnaire.;Anxiety score in Beck questionnaire. Timepoint: Measurement of the Anxiety score at the beginning of the study (before the start of the intervention) and 6 weeks after the start of the modified psychobiotic diet. Method of measurement: Beck Anxiety Questionnaire.;Food Addiction Score in the Yale Food Addiction Questionnaire. Timepoint: Measuring the food addiction score at the beginning of the study (before the intervention) and 6 weeks after the start of the modified psychobiotic diet. Method of measurement: Yale Food Addiction Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Trimethylamine-N oxide. Timepoint: The beginning of the study (before the start of the intervention) and 6 weeks after the start of psychobiotic diet. Method of measurement: Trimethylamine N-oxide kit (Zelbio ).;Leptin. Timepoint: The beginning of the study (before the start of the intervention) and 6 weeks after the start of the psychobiotic diet. Method of measurement: Leptin assay kit- Human.;Lipid profile. Timepoint: The beginning of the study (before the start of the intervention) and 6 weeks after the start of the psychobiotic diet. Method of measurement: Lipid profile assay laboratory kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammadjavad Hosseinzadeh Attar
Tehran University of Medical Sciences
Outcome results
None listed