Comparison of Efficacy of Two Hybrid Regimens (10 days and 14 days )for Eradication of Helicobacter pylori Infection

Comparison of Efficacy of Two Hybrid regimens (10 days and 14 days ) for Eradication of Helicobacter Pylori Infection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013112415510N1

Enrollment

250

Registered

2014-02-02

Start date

2013-12-31

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric ulcer. gastric ulcer

Interventions

Intervention 1: Intervention group (10 days hybrid regimen): Pantoprazole 40 mgr / twice daily for 10 days and Amoxicillin 1 gr every 12 hours for 10 days and Clarithromycin 500 mgr + Tinidazole 500 m

Treatment - Drugs

Intervention group (10 days hybrid regimen): Pantoprazole 40 mgr / twice daily for 10 days and Amoxicillin 1 gr every 12 hours for 10 days and Clarithromycin 500 mgr + Tinidazole 500 mgr every 12 hour

Control group ( 14 days hybrid regimen): ( Pantoprazole 40mgr / BID for 14 days and Amoxicillin 1 gr twice every 12 hours for 14 days and Clarithromycin 500 mgr + tinidazole 500 mgr every 12 hours for

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with endoscopic findings of gastric or duodenal ulcer or gastric and duodenal erosoin ; Helicobacter pylori infection ; patients older than 18 year and less than 80 years. Exclusion criteria : pregnancy and lactation ; previously received Helicobacter pylori therapy ; patients received PPI (poroton poup inhibitor) or H2 RA (histamine 2 receptor antagonist) in last 2 weeks or within 4 weeks who received antibiotics ; history of surgery on the stomach ; Patients with confirmed advanced disease , severe cardiac, pulmonary , endocrine , chronic renal failure, chronic liver disease or have cancer ; The consumption of alcoholic beverages

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Helicobacter Pylori Infection. Timepoint: Before the intervention, and 12 weeks after intervention. Method of measurement: Before intervention, endoscopy and biopsy and RUT(Rapid urease Test), and after intervention endoscopy and biopsy and RUT(Rapid Urease Test ) and or UBT (Urea Breath Test ).	—

Secondary

Measure	Time frame
Helicobacter Pylori Infection eradication rate, Hybrid regimes complication rate and patient compliance. Timepoint: 12 weeks after initiation of thrapy regimens. Method of measurement: Questionnaire and endoscopy and biopsy and or UBT (Urea Breath Test).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mohammad Valizadeh Toosi

Sari Emam Khomeni Hospital, Gastroenterology Research Center

sm.valizadehtoosi@mazums.ac.ir seyedmohammadv@yahoo.com+98 15 1226 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026